Clotrimazole Binds to Heme and Enhances Heme-dependent Hemolysis
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چکیده
منابع مشابه
How O2 Binds to Heme
We have used density functional methods to calculate fully relaxed potential energy curves of the seven lowest electronic states during the binding of O2 to a realistic model of ferrous deoxyheme. Beyond a Fe–O distance of 2.5 Å, we find a broad crossing region with five electronic states within 15 kJ/mol. The almost parallel surfaces strongly facilitate spin inversion, which is necessary in th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m107285200